Get medical attention if irritation develops and persists. List of drug master files dmf of doxapram hcl active pharmaceutical ingredient api submitted to the u. Doxapram hydrochloride 6151733 7081530 2% components not listed are not hazardous or are below reportable limits. Doxapram hcl prescription price comparison compare drug. How supplied dopram injection doxapram hydrochloride injection, usp is available in boxes of six 20 ml multiple dose vials containing 20 mg of doxapram hydrochloride per ml with benzyl alcohol 0. Identification of the substancemixture and of the companyundertaking.
Conforms to hazcom 2012united states safety data sheet. When combined with physiotherapy, doxapram can encourage coughing and clearance of excessive secretions. Consumer information about the medication doxapram injection dopram, includes side effects, drug interactions, recommended dosages, and storage information. Doxapram manufacturer in india doxapram hydrochloride injection usp exporter in india doxapram 20mg largest generic manufacturer,drugs,formula,producing doxapram msds,coa, pdf,doc chemical api method according to the present doxapram invention suppliers list,molecular structure,weight,iupac,synonyms for doxapram. Theeffects of respiratory stimulation are a result of direct stimulation of the medullary respiratorycenters and possibly through the reflex activation of carotid and aortic chemoreceptors. Hazardous polymerization not anticipated to occur with this product. Doxapram inhibits both task1 and task3 function in a dose dependent manner. When doxapram is mixed with minocycline hydrochloride, there is a loss of 8% of doxapram in 3 hours and a % loss of doxapram in 6 hours. Doxapram hydrochloride inhibits task1, task3, task1task3 heterodimeric channel function with ec50 of 410 nm, 37. Cb839telaglenastat new cb839 is a potent, selective, and orally bioavailable glutaminase inhibitor with ic50 of 24 nm for recombinant human gac. Firefighting measures suitable extinguishing media water fog. Handling and storage conditions for safe storage, including any incompatibilities store in accordance with local regulations. Safety data sheet according to federal register vol. Used to stiumulate respiration in dogs, cats and horses during and after general anesthesia, or to.
In vitro, doxapram stimulates catecholamine release preferentially dopamine from carotid bodies. Material safety data sheet of doxapram hydrochloride contains identification of substance and details of the supplier of the safety data sheet. Prepare 1mgml solution by adding 250 mg of doxapram hydrochloride 12. Doxapram hydrochloride european pharmacopoeia ep reference standard synonym.
Empirical formula hill notation c 24 h 30 n 2 o 2 hcl h 2 o. Doxapram hydrochloride monohydrate c24h33cln2o3 cid 64648 structure, chemical names, physical and chemical properties, classification, patents. Doxapram hcl hplc method and application note knowledge. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online. The text only version may be available in large print, braille or audio cd. On the basis of equality and mutual benefit, and under the principle of customer first. Below is a text only representation of the patient information leaflet. Show this safety data sheet to the doctor in attendance. Store in original container protected from direct sunlight in a dry, cool and wellventilated area, away from incompatible materials see section 10 and food and drink. Doxapram may stimulation respiration in dogs, cats, and horses during and after general anesthesia. Doxapram hydrochloride monograph for professionals.
Material safety data sheet of doxapram hydrochloride. Firstaid measures if breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. New role for fdaapproved drugs in combating antibiotic. Identification of the substancemixture and of the companyundertaking product name. Section 33, and the msds contains all required information. Chemically, doxapram hydrochloride is 1ethyl424morpholinylethyl3,3diphenyl2pyrrolidinone monohydrochloride, monohydrate. Reference doxapram hydrochloride was obtained from usp u. Doxapram is a member of the class of pyrrolidin2ones that is nethylpyrrolidin2one in which both of the hydrogens at the 3 position adjacent to the carbonyl group are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2morpholin4ylethyl group. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Our msds database is an easy to use, do it yourself tool, and best of all.
Wash contaminated clothing before reuse store in a well ventilated place. It is said that the carboxy terminal domain of task1 is important to doxapram inhibition. Pharmacology, adverse reactions, warnings and side effects. Assay of doxapram hcl by an hplc method is provided in this application note. Capitals indicate lifethreatening, underlines indicate most frequent. Pharmacology doxapram hcl doxapram is a general cns stimulant, with all levels of the cns affected. Doxapram, independent of oxygen levels, directly stimulates the peripheral carotid chemoreceptors, possibly by inhibiting the potassium channels of type i cells within the carotid body, thereby stimulating catecholamines release. For further information call emc accessibility on 0800 198 5000. Doxapram is a respiratory stimulant with analeptic activity.
Doxapram only slightly reduces the shivering threshold in healthy. Doxapram hydrochloride hydrate safety data sheet according to regulation ec no. Animals or persons developing anaphylactic lifethreatening reactions, such as difficulty in breathing or unconsciousness, must receive immediate medical attention. Prepare 2mgml solution by adding 400 mg of doxapram hydrochloride 20 ml to 180 ml of 5% dextrose, 10% dextrose, or 0. Date of preparation dopramv injectable doxapram hydrochloride not applicable. Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem appearance. Use our prescription price comparison tool to find the best prescription drug price for doxapram hcl in your area, then use our prescription discount card to save even more. Doxapram manufacturer, doxapram hydrochloride injection. Chemical product and company identification manufacturer name and address hospira, inc. Doxapram hydrochloride drug information, uses, side. Watsonnoke scientific ltd develops doxapram hcl cas 7081530 98%100. Emergency telephone number with hours of operation. Adsorption to sediment and bioconcentration in aquatic organisms may not be important fate process for oxalic acid.
Doxapram has a limited place in the shortterm treatment of ventilatory failure, such as in hypercapnoeic respiratory failure due to chronic obstructive pulmonary disease which is causing drowsiness. Doxapram hydrochloride 7081530 2 chemical name cas number % 4. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. It has been used to stimulate respiration in newborn animals following dystocia or cesarean section surgery. Dopram injection doxapram hydrochloride injection, usp is available in boxes of six 20 ml multiple dose vials containing 20 mg of doxapram hydrochloride per ml with benzyl alcohol 0. The original leaflet can be viewed using the link above. Javascript must be enabled in order for you to use knowledgebase manager pro. Doxapram hydrochloride hydrate safety data sheet section 2. Read more about the prescription drug doxapram injection. P202 do not handle until all safety precautions have been read and understood p210 keep away from heatsparksopen flameshot surfaces.
This results in the prevention or reversal of both narcotic and cns depressantinduced respiratory. It is soluble in water, sparingly soluble in alcohol and practically insoluble in ether. Doxapram is a white to offwhite, odorless, crystalline powder that is stable in light and air. Doxapram hcl injection respiratory stimulant doxapram treats breathing problems after surgery or drug overdose.
Doxapram hydrochloride bp 20mgml solution for injection. After centrifugation, the cell pellets were dissolved in sds. Doxapram hydrochloride is a white to offwhite, crystalline powder, sparingly soluble in water, alcohol and chloroform. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. Setanaxib gkt7831 new gkt7831 is a potent, dual nadph oxidase nox1nox4 inhibitor with ki of 110 nm and 140 nm, respectivelyl. Doxapram injection dopram side effects, medical uses. Safety data sheet according to 29cfr19101200 and ghs rev. Formation of toxic gases is possible during heating or fire. Dopram prescription and dosage sizes information for physicians and healthcare professionals. A wide variety of doxapram hcl options are available to you, such as medicine grade, food grade.
Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Doxapram hydrochloride cas 7081530 abmole bioscience. Data were analyzed with paired t tests and presented as means sds. Material may be irritating to the mucous membranes and upper respiratory tract. For research use only, not for human or veterinary use. Doxapram hydrochloride c24h31cln2o2 cid 64647 structure, chemical names, physical and chemical properties, classification, patents, literature, biological. Doxapram hydrochloride monohydrate c24h33cln2o3 pubchem. Inhalation skin contact rinse skin with watershower. During all fire fighting activities, wear appropriate protective equipment, including self contained breathing apparatus. Doxapram hcl cas 7081530, find complete details about doxapram hcl cas 7081530,cas 7081530,doxapram,doxapram hcl from animal pharmaceuticals supplier or. Doxapram inhibition at both hyperpolarized and depolarized potentials, as well as effects independent of extracellular potassium concentration. Product identifier doxapram hcl other means of identification none.
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